PTPRB Antibody | MyBioSource MBS9387081 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PTPRB Antibody

catalog :

MBS9387081

quantity :

0.1 mL

price :

440 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts from Pc12, using PTPRB Ab. The lane on the left was treated with blocking peptide.

image 2 :

Western blot analysis of extracts from Pc12, using PTPRB Ab. The lane on the left was treated with blocking peptide.

product information

catalog number :

MBS9387081

products type :

Antibody

products full name :

PTPRB Antibody

products short name :

[PTPRB]

other names :

[receptor-type tyrosine-protein phosphatase beta isoform a; Receptor-type tyrosine-protein phosphatase beta; receptor-type tyrosine-protein phosphatase beta; protein tyrosine phosphatase, receptor type B; Vascular endothelial protein tyrosine phosphatase; VE-PTP]

products gene name :

[PTPRB]

other gene names :

[PTPRB; PTPRB; PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA; PTPB; Protein-tyrosine phosphatase beta; R-PTP-beta; VE-PTP]

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Rat

sequence length :

2215

specificity :

PTPRB Ab detects endogenous levels of total PTPRB.

purity :

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin

form :

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 °C. Stable for 12 months from date of receipt.

tested application :

Western Blot (WB)

app notes :

WB: 1:1000-3000. Important: For western blot, incubate membrane with diluted primary Ab in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight.

image1 heading :

Western blot

image2 heading :

Western blot

other info1 :

Immunogen: A synthesized peptide derived from human PTPRB.

other info2 :

Subcellular Location: Membrane. Tissue Specificity: Up-regulated by hypoxia. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

ncbi gi num :

157952215

ncbi acc num :

NP_001103224.1

ncbi gb acc num :

NM_001109754.3

uniprot acc num :

P23467

ncbi mol weight :

224kDa

ncbi pathways :

Adherens Junction Pathway (83070); Adherens Junction Pathway (481)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

uniprot summary :

PTPRB: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine. Chromosomal Location of Human Ortholog: 12q15. Cellular Component: integral to plasma membrane; receptor complex. Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity. Biological Process: dephosphorylation; phosphate metabolic process; protein amino acid dephosphorylation

size1 :

0.1 mL

price1 :

440 USD

size2 :

0.2 mL

price2 :

715

more info or order :

MyBioSource product webpage