product summary
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company name :
MyBioSource
product type :
antibody
product name :
IRS2 (Phospho-Ser1100) Antibody
catalog :
MBS9385622
quantity :
0.1 mL
price :
440 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot
more info or order :
image
image 1 :
Western blot analysis IRS2 (Phospho-Ser1100) using Mouse brain tissue lysates. Important:. For western blot, incubate membrane with diluted primary Ab in 5% w/v milk , 1X TBS, 0.1% Tween ® 20 at 4°C with gentle shaking, overnight.
product information
catalog number :
MBS9385622
products type :
Antibody
products full name :
IRS2 (Phospho-Ser1100) Antibody
products short name :
[IRS2]
products name syn :
[Insulin receptor substrate 2; IRS 2; IRS-2; Irs2; IRS2_HUMAN]
other names :
[insulin receptor substrate 2; Insulin receptor substrate 2; insulin receptor substrate 2; insulin receptor substrate 2]
products gene name :
[IRS2]
other gene names :
[IRS2; IRS2; IRS-2; IRS-2]
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse
specificity :
IRS2 (Phospho-Ser1100) Antibody detects endogenous levels of IRS2 only when phosphorylated at Ser1100
purity :
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
form :
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
concentration :
1mg/ml
storage stability :
Store at -20°C. Stable for 12 months from date of receipt.
tested application :
Western Blot
app notes :
WB: 1:1000-3000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthesized peptide derived from human IRS2 (Phospho-Ser1100). Subcellular Location: Cytoplasm > Cytosol
ncbi gi num :
38683860
ncbi acc num :
NP_003740.2
ncbi gb acc num :
NM_003749.2
uniprot acc num :
Q9Y4H2
ncbi mol weight :
137kDa
ncbi pathways :
Adaptive Immune System Pathway (366160); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); Alpha6-Beta4 Integrin Signaling Pathway (198807); BDNF Signaling Pathway (712093); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)
ncbi summary :
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
uniprot summary :
IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: cytosol; plasma membrane. Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; Ras guanyl-nucleotide exchange factor activity. Biological Process: cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; lipid homeostasis; MAPKKK cascade; negative regulation of B cell apoptosis; negative regulation of kinase activity; phosphoinositide-mediated signaling; positive regulation of B cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; regulation of lipid metabolic process; regulation of phosphoinositide 3-kinase cascade; response to glucose stimulus; signal transduction. Disease: Diabetes Mellitus, Noninsulin-dependent
size1 :
0.1 mL
price1 :
440 USD
size2 :
0.2 mL
price2 :
715
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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