antibody

glut2 Antibody

MBS9385022

0.1 mL

440 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

glut2 Antibody

[glut2]

[SLC2A2, GLUT-2, GLUT2, Glucose transporter 2]

[solute carrier family 2, facilitated glucose transporter member 2 isoform 1; Solute carrier family 2, facilitated glucose transporter member 2; solute carrier family 2, facilitated glucose transporter member 2; solute carrier family 2 member 2; Glucose transporter type 2, liver; GLUT-2]

[glut2]

[SLC2A2; SLC2A2; GLUT2; GLUT2; GLUT-2]

polyclonal

Rabbit IgG

rabbit

Human, Mouse, Rat

524

glut2 Antibody detects endogenous levels of total glut2

Immunogen affinity purified

Store at -20 degree C.

Western Blot (WB)

WB 1:500-1:2000. Optimal dilutions/concentrations should be determined by the end user.

Western blot

Immunogen: A synthesized peptide derived from human glut2

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008]

4557851

NP_000331.1

NM_000340.1

P11168

57 kDa.

Carbohydrate Digestion And Absorption Pathway (170720); Carbohydrate Digestion And Absorption Pathway (170654); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Developmental Biology Pathway (1270302); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Facilitative Na+-independent Glucose Transporters Pathway (1269924); Glucagon Signaling Pathway (1144996); Glucagon Signaling Pathway (1158201); Glucose Transport Pathway (1269921)

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family. Chromosomal Location of Human Ortholog: 3q26.2. Cellular Component: integral to plasma membrane; membrane; plasma membrane. Molecular Function: D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity. Biological Process: carbohydrate metabolic process; glucose transport; hexose transport; regulation of insulin secretion. Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi-bickel Syndrome

0.1 mL

440 USD

0.2 mL

715