product summary
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company name :
MyBioSource
product type :
antibody
product name :
EDEM3 Antibody
catalog :
MBS9384638
quantity :
0.1 mL
price :
440 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS9384638 image 1
Western blot analysis EDEM3 using HeLa whole cell lysates.
product information
catalog number :
MBS9384638
products type :
Antibody
products full name :
EDEM3 Antibody
products short name :
[EDEM3]
products name syn :
[alpha-1,2-mannosidase EDEM3; C1orf22; EDEM 3; edem3; EDEM3_HUMAN; ER degradation enhancer, mannosidase alpha like 3; ER degradation enhancing alpha mannosidase like 3; ER degradation enhancing alpha mannosidase like protein 3; ER degradation-enhancing alpha-mannosidase-like 3;]
other names :
[ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 1; ER degradation-enhancing alpha-mannosidase-like protein 3; ER degradation-enhancing alpha-mannosidase-like protein 3; ER degradation enhancing alpha-mannosidase like protein 3; Alpha-1,2-mannosidase EDEM3]
products gene name :
[EDEM3]
other gene names :
[EDEM3; EDEM3; C1orf22; C1orf22]
clonality :
polyclonal
isotype :
IgG
host :
rabbit
reactivity :
Human, Mouse
sequence length :
948
sequence :
MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTA
GAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELM
PLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVL
NKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLL
GGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFN
TTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLIL
EFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVT
INIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFL
ERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDAL
LAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFT
TDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTL
IENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFK
YLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSI
SKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIR
EPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATN
PEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAED
GLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVL
TAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAV
MGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSS
SDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
EYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQ
ISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASI
SPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDS
NPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
specificity :
EDEM3 Antibody detects endogenous levels of total EDEM3
purity :
Immunogen affinity purified
concentration :
1.0mg/ml
storage stability :
Store at -20 degree C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB)
app notes :
Optimal dilutions/concentrations should be determined by the end user.
image1 heading :
Western blot
other info1 :
Immunogen: A synthesized peptide derived from human EDEM3. Subcellular Location: Endoplasmic reticulum lumen. Similarity: Belongs to the glycosyl hydrolase 47 family.
other info2 :
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
products description :
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).
ncbi gi num :
985801665
ncbi acc num :
NP_001306889.1
ncbi gb acc num :
NM_001319960.1
uniprot acc num :
Q9BZQ6
ncbi mol weight :
105kDa
ncbi pathways :
Asparagine N-linked Glycosylation Pathway (1268714); Calnexin/calreticulin Cycle Pathway (1268723); ER Quality Control Compartment (ERQC) Pathway (1268724); Metabolism Of Proteins Pathway (1268677); N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway (1268722); Post-translational Protein Modification Pathway (1268701); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190)
ncbi summary :
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
uniprot summary :
EDEM3: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity. Belongs to the glycosyl hydrolase 47 family. Protein type: EC 3.2.1.113; Hydrolase. Chromosomal Location of Human Ortholog: 1q25.3. Cellular Component: endoplasmic reticulum. Molecular Function: alpha-mannosidase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Biological Process: ER-associated protein catabolic process; N-glycan processing; unfolded protein response
size1 :
0.1 mL
price1 :
440 USD
size2 :
0.2 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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