catalog number :
MBS9384073
products full name :
CD68 Antibody
products short name :
[CD68]
other names :
[macrosialin isoform B; Macrosialin; macrosialin; CD68 molecule; Gp110; CD_antigen: CD68]
products gene name :
[CD68]
other gene names :
[CD68; CD68; GP110; LAMP4; SCARD1]
reactivity :
Human,Mouse,Rat
specificity :
ATF-4 (Phospho-Ser219) Ab detects endogenous levels of total ATF-4 (Phospho-Ser219).
purity :
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (ThermoFisher Scientific).
storage stability :
Store at -20°C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western Blot (WB)1:1000-3000. Immunohistochemistry (IHC) 1:200
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
ncbi acc num :
NP_001035148.1
ncbi gb acc num :
NM_001040059.1
ncbi pathways :
Lysosome Pathway (99052); Lysosome Pathway (96865)
ncbi summary :
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
uniprot summary :
CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: membrane