antibody

CD20 Antibody

MBS9383021

0.1 mL

440 USD

polyclonal

rabbit

nonconjugated

Antibody

CD20 Antibody

[CD20]

[APY, ATOPY, B lymphocyte antigen CD20, B-lymphocyte surface antigen B1?Bp 35? CD 20?CD20 antigen?CVID5?]

[B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; membrane spanning 4-domains A1; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20]

[CD20]

[MS4A1; MS4A1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; CD20]

polyclonal

Rabbit IgG

rabbit

Human

297

Immunogen affinity purified

1.0mg/ml

Store at -20 °C.Stable for 12 months from date of receipt.

Western Blot (WB)

WB: 1:500-1:2000. Optimal dilutions/concentrations should be determined by the end user.

Western blot

Background/Introduction: CD20 (MS4A1, membrane-spanning 4-domains, subfamily A, member 1) is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit. And it is known to accelerate the G0 to G1 progression induced by IGF-1.

23110987

NP_068769.2

NM_021950.3

P11836

33kDa

Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family. Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11q12.2. Cellular Component: extracellular space. Molecular Function: protein binding. Disease: Immunodeficiency, Common Variable, 5

0.1 mL

440 USD

0.2 mL

715