Rat Kalirin (KALRN) ELISA Kit | MyBioSource MBS9369019 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Kalirin (KALRN) ELISA Kit

catalog :

MBS9369019

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9369019

products type :

ELISA Kit

products full name :

Rat Kalirin (KALRN) ELISA Kit

products short name :

[Kalirin (KALRN)]

other names :

[kalirin; Kalirin; kalirin; kalirin, RhoGEF kinase; Huntingtin-associated protein-interacting protein; PAM COOH-terminal interactor protein 10; P-CIP10; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain]

products gene name :

[KALRN]

other gene names :

[Kalrn; Kalrn; Duo; Hapip; Kalirin; Duo; Hapip; P-CIP10]

uniprot entry name :

KALRN_RAT

reactivity :

Rat

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of KALRN (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

295054252

ncbi acc num :

NP_114451.2

ncbi gb acc num :

NM_032062.2

ncbi mol weight :

81,973 Da

ncbi pathways :

Axon Guidance Pathway (1333217); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (1333847); Developmental Biology Pathway (1333216); EPH-Ephrin Signaling Pathway (1333237); EPHB-mediated Forward Signaling Pathway (1333239); G Alpha (12/13) Signalling Events Pathway (1333969); G Alpha (q) Signalling Events Pathway (1333968); GPCR Downstream Signaling Pathway (1333964); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1333982); MAPK Family Signaling Cascades Pathway (1333896)

ncbi summary :

binds the human huntingtin associated protein Hap1 in vitro; has GDP/GTP exchange factor activity for Rho subfamily GTP-binding proteins [RGD, Feb 2006]

uniprot summary :

kalirin: a bifunctional enzyme with protein kinase activity and guanine-exchange factor (GEF) activity. A protein kinase of the CAMK group. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Genetic variants are associated with susceptibility to coronary heart disease type 5 (CHDS5), a multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) Interacts with FASLG. The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity. 6 isoforms of the human protein are produced by alternative splicing. Isoform 2 is brain specific and is highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. Protein type: Kinase, protein; GEFs, Rac/Rho; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; GEFs; CAMK group; Trio family. Cellular Component: cell soma; cytoskeleton; neuron projection; perinuclear region of cytoplasm. Molecular Function: ATP binding; enzyme binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity. Biological Process: axonogenesis; nervous system development; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of dendrite development; regulation of Rho protein signal transduction

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095