ELISA/assay

Hamster S-Adenosylmethionine Synthase Isoform Type-1 (MAT1A) ELISA Kit

MBS9368348

48-Strip-Wells

470 USD

ELISA Kit

Hamster S-Adenosylmethionine Synthase Isoform Type-1 (MAT1A) ELISA Kit

[S-Adenosylmethionine Synthase Isoform Type-1 (MAT1A)]

[S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthase isoform type-1; methionine adenosyltransferase 1A; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III]

[MAT1A]

[MAT1A; MAT1A; MAT; SAMS; MATA1; SAMS1; AMS1; MATA1; AdoMet synthase 1; MAT 1; MAT-I/III]

METK1_HUMAN

Hamster

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MAT1A (hereafter termed "analyte") in undiluted original Hamster body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

4557737

NP_000420.1

NM_000429.2

43,648 Da

Biological Oxidations Pathway (1270189); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Cysteine And Methionine Metabolism Pathway (104488); Cysteine And Methionine Metabolism Pathway (103421); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); Metabolism Of Ingested SeMet, Sec, MeSec Into H2Se Pathway (1339150); Methionine Degradation Pathway (413353)

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

MAT1A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD); also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Belongs to the AdoMet synthase family. Protein type: Transferase; EC 2.5.1.6; Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid. Chromosomal Location of Human Ortholog: 10q22. Cellular Component: cytosol. Molecular Function: ATP binding; metal ion binding; methionine adenosyltransferase activity. Biological Process: amino acid metabolic process; methylation; one-carbon compound metabolic process; S-adenosylmethionine biosynthetic process; selenium metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process. Disease: Methionine Adenosyltransferase Deficiency

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095