Mouse RE1-Silencing Transcription Factor (REST) ELISA Kit | MyBioSource MBS9366383 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse RE1-Silencing Transcription Factor (REST) ELISA Kit

catalog :

MBS9366383

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9366383

products type :

ELISA Kit

products full name :

Mouse RE1-Silencing Transcription Factor (REST) ELISA Kit

products short name :

[RE1-Silencing Transcription Factor (REST)]

other names :

[RE1-silencing transcription factor; RE1-silencing transcription factor; RE1-silencing transcription factor; RE1 silencing transcription factor; Neural-restrictive silencer factor; X2 box repressor]

products gene name :

[REST]

other gene names :

[REST; REST; WT6; XBR; NRSF; NRSF; XBR]

uniprot entry name :

REST_HUMAN

reactivity :

Mouse

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of REST (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

301897977

ncbi acc num :

NP_001180437.1

ncbi gb acc num :

NM_001193508.1

ncbi mol weight :

119,083 Da

ncbi pathways :

Chromatin Modifying Enzymes Pathway (1270434); Chromatin Organization Pathway (1270433); HDACs Deacetylate Histones Pathway (1270436); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); SIDS Susceptibility Pathways (198901); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502)

ncbi summary :

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

uniprot summary :

REST: a transcriptional repressor that binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells during embryonic development. Induced during ageing in human cortical and hippocampal neurons, where it represses genes that promote cell death and induces the expression of stress response genes. Protects neurons from amyloid beta- and oxidative stress-induced toxicity. The deletion of REST in the mouse brain induces age-related neurodegeneration. Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. REST activates DYRK1A transcription via a neuron-restricted silencer element in the DYRK1A promoter. Four isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Cell development/differentiation; DNA-binding; C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 4q12. Cellular Component: chromatin; cytosol; nucleoplasm; nucleus; transcriptional repressor complex. Molecular Function: chromatin binding; metal ion binding; outward rectifier potassium channel activity; protein binding; protein complex binding; transcription factor activity; transcription factor binding. Biological Process: establishment and/or maintenance of chromatin architecture; hemopoietic progenitor cell differentiation; negative regulation of aldosterone biosynthetic process; negative regulation of calcium ion-dependent exocytosis; negative regulation of cell proliferation; negative regulation of insulin secretion; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage