ELISA/assay

Camel Arginine Vasopressin Receptor 2 (AVPR2) ELISA Kit

MBS9363909

48-Strip-Wells

470 USD

ELISA Kit

Camel Arginine Vasopressin Receptor 2 (AVPR2) ELISA Kit

[Arginine Vasopressin Receptor 2 (AVPR2)]

[arginine vasopressin receptor 2; Vasopressin V2 receptor; vasopressin V2 receptor; arginine vasopressin receptor 2; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor]

[AVPR2]

[AVPR2; AVPR2; DI1; DIR; NDI; V2R; ADHR; DIR3; ADHR; DIR; DIR3; V2R; V2R]

V2R_HUMAN

Camel

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of AVPR2 (hereafter termed "analyte") in undiluted original Camel body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

29825389

AAO92298.1

33,743 Da

Aquaporin-mediated Transport Pathway (1269944); Arf6 Trafficking Events Pathway (137954); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Defective AVP Causes Neurohypophyseal Diabetes Insipidus (NDI) Pathway (1309124); Disease Pathway (1268854); Disorders Of Transmembrane Transporters Pathway (1268932); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886)

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]

AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, GPCR; GPCR, family 1; Transporter, aquaporin family; Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: endoplasmic reticulum; endosome; Golgi apparatus; integral to membrane; integral to plasma membrane; plasma membrane. Molecular Function: peptide binding; protein binding; vasopressin receptor activity. Biological Process: adenylate cyclase activation; cellular response to hormone stimulus; excretion; G-protein signaling, coupled to cAMP nucleotide second messenger; hemostasis; I-kappaB kinase/NF-kappaB cascade; interferon-gamma production; positive regulation of cell proliferation; positive regulation of protein ubiquitination; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; renal water homeostasis; response to cytokine stimulus; telencephalon development; transmembrane transport; water transport. Disease: Diabetes Insipidus, Nephrogenic, X-linked; Nephrogenic Syndrome Of Inappropriate Antidiuresis

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095