Human Endothelial PAS Domain-Containing Protein 1 (EPAS1) ELISA Kit | MyBioSource MBS9361593 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Endothelial PAS Domain-Containing Protein 1 (EPAS1) ELISA Kit

catalog :

MBS9361593

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9361593

products type :

ELISA Kit

products full name :

Human Endothelial PAS Domain-Containing Protein 1 (EPAS1) ELISA Kit

products short name :

[Endothelial PAS Domain-Containing Protein 1 (EPAS1)]

other names :

[endothelial PAS domain-containing protein 1; Endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1; endothelial PAS domain protein 1; Basic-helix-loop-helix-PAS protein MOP2; Class E basic helix-loop-helix protein 73; bHLHe73; HIF-1-alpha-like factor; HLF; Hypoxia-inducible factor 2-alpha; HIF-2-alpha; HIF2-alpha; Member of PAS protein 2; PAS domain-containing protein 2]

products gene name :

[EPAS1]

other gene names :

[EPAS1; EPAS1; HLF; MOP2; ECYT4; HIF2A; PASD2; bHLHe73; BHLHE73; HIF2A; MOP2; PASD2; EPAS-1; bHLHe73; HLF; HIF-2-alpha; HIF2-alpha]

uniprot entry name :

EPAS1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 pg/ml - 100 pg/ml. Sensitivity: 1.0 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of EPAS1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

40254439

ncbi acc num :

NP_001421.2

ncbi gb acc num :

NM_001430.4

ncbi mol weight :

96,459 Da

ncbi pathways :

Adipogenesis Pathway (198832); Cellular Response To Hypoxia Pathway (1270415); Cellular Responses To Stress Pathway (1270414); Developmental Biology Pathway (1270302); HIF-2-alpha Transcription Factor Network Pathway (137956); Oxygen-dependent Asparagine Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway (1270417); Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway (1270418); Pathways In Cancer (83105); Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway (1270416); Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway (1270419)

ncbi summary :

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]

uniprot summary :

HIF2A: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBBP. Interacts with EGLN1. Interacts with VHL. Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 2p21-p16. Cellular Component: cytosol; nuclear speck; nucleoplasm; transcription factor complex. Molecular Function: DNA binding; histone acetyltransferase binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding. Biological Process: angiogenesis; blood vessel remodeling; cell maturation; embryonic placenta development; erythrocyte differentiation; iron ion homeostasis; lung development; mitochondrion organization and biogenesis; myoblast cell fate commitment; norepinephrine metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of heart rate; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to hypoxia; signal transduction; somatic stem cell maintenance; surfactant homeostasis; transcription from RNA polymerase II promoter; visual perception. Disease: Erythrocytosis, Familial, 4

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage