catalog number :
MBS9361085
products type :
ELISA Kit
products full name :
Canine Protein Argonaute-2 (AGO2) ELISA Kit
products short name :
[Protein Argonaute-2 (AGO2)]
other names :
[protein argonaute-2 isoform 2; Protein argonaute-2; protein argonaute-2; argonaute 2, RISC catalytic component; Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2]
products gene name :
[AGO2]
other gene names :
[AGO2; AGO2; Q10; EIF2C2; EIF2C2; Argonaute2; hAgo2; eIF-2C 2; eIF2C 2; PPD]
uniprot entry name :
AGO2_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml
other info2 :
Intra-assay Precision: Intra-assay CV(%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of AGO2 (hereafter termed "analyte") in undiluted original Canine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001158095.1
ncbi gb acc num :
NM_001164623.1
ncbi mol weight :
93,620 Da
ncbi pathways :
Adaptive Immune System Pathway (1269171); Beta-catenin Independent WNT Signaling Pathway (1269610); Ca2+ Pathway (1269615); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Downstream Signal Transduction Pathway (1269479); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (1269185); Downstream Signaling Of Activated FGFR1 Pathway (1269392); Downstream Signaling Of Activated FGFR2 Pathway (1269403); Downstream Signaling Of Activated FGFR3 Pathway (1269413)
ncbi summary :
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
uniprot summary :
AGO2: the endonuclease in RNA-induced silencing complexes (RISC) that cleaves siRNA/mRNA heteroduplexes bound to RISC. Ago2, along with Dicer and TRBP, are major components of RISC. Interacts with Dicer1 through its Piwi domain. Required for proper fibroblast growth factor signaling during gastrulation. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi). Protein type: EC 3.1.26.n2; RNA processing; RNA-binding. Chromosomal Location of Human Ortholog: 8q24. Cellular Component: cytoplasm; cytosol; dendrite; membrane; mRNA cap complex; nucleoplasm; nucleus; polysome; ribonucleoprotein complex. Molecular Function: double-stranded RNA binding; endoribonuclease activity; metal ion binding; miRNA binding; mRNA binding; protein binding; protein C-terminus binding; RNA 7-methylguanosine cap binding; single-stranded RNA binding; siRNA binding; translation initiation factor activity. Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; innate immune response; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; negative regulation of translational initiation; nerve growth factor receptor signaling pathway; Notch signaling pathway; phosphoinositide-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; pre-microRNA processing; RNA interference, siRNA loading onto RISC; RNA secondary structure unwinding; RNA-mediated gene silencing; RNA-mediated posttranscriptional gene silencing; transcription, DNA-dependent; translation; translational initiation
size4 :
10x96-Strip-Wells