Human G Protein-Coupled Receptor Kinase 5 (GRK5) ELISA Kit | MyBioSource MBS9359790 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human G Protein-Coupled Receptor Kinase 5 (GRK5) ELISA Kit

catalog :

MBS9359790

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9359790

products type :

ELISA Kit

products full name :

Human G Protein-Coupled Receptor Kinase 5 (GRK5) ELISA Kit

products short name :

[G Protein-Coupled Receptor Kinase 5 (GRK5)]

other names :

[G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5]

products gene name :

[GRK5]

other gene names :

[GRK5; GRK5; GPRK5; GPRK5]

uniprot entry name :

GRK5_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GRK5 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

4885349

ncbi acc num :

NP_005299.1

ncbi gb acc num :

NM_005308.2

ncbi mol weight :

67,787 Da

ncbi pathways :

Alpha-synuclein Signaling Pathway (137913); Calcium Regulation In The Cardiac Cell Pathway (198906); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Endocytosis Pathway (102279); Endocytosis Pathway (102181); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Morphine Addiction Pathway (552665)

ncbi summary :

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

uniprot summary :

GRK5: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70- interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2- mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G- protein-coupled receptor, LRP6 during Wnt signaling (in vitro). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Protein type: Protein kinase, AGC; EC 2.7.11.16; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; GRK family; GRK subfamily. Chromosomal Location of Human Ortholog: 10q26.11. Cellular Component: cytoplasm; focal adhesion; nuclear membrane; nucleus; plasma membrane. Molecular Function: ATP binding; beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity; phospholipid binding; protein binding; protein kinase C binding; protein serine/threonine kinase activity. Biological Process: apoptosis; desensitization of G-protein coupled receptor protein signaling pathway; fat cell differentiation; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of apoptosis; positive regulation of cell proliferation; protein amino acid autophosphorylation; regulation of cell cycle; regulation of G-protein coupled receptor protein signaling pathway; response to drug; tachykinin signaling pathway; Wnt receptor signaling pathway

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095