Human Dynamin-1-Like Protein (DNM1L) ELISA Kit | MyBioSource MBS9358522 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Dynamin-1-Like Protein (DNM1L) ELISA Kit

catalog :

MBS9358522

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9358522

products type :

ELISA Kit

products full name :

Human Dynamin-1-Like Protein (DNM1L) ELISA Kit

products short name :

[Dynamin-1-Like Protein (DNM1L)]

other names :

[dynamin-1-like protein; Dynamin-1-like protein; dynamin-1-like protein; dynamin 1-like; Dynamin-like protein]

products gene name :

[DNM1L]

other gene names :

[Dnm1l; Dnm1l; DLP1; Drp1; Dnml1; Dlp1]

uniprot entry name :

DNM1L_RAT

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DNM1L (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

77917614

ncbi acc num :

NP_446107.2

ncbi gb acc num :

NM_053655.3

ncbi mol weight :

80,104 Da

ncbi pathways :

Apoptosis Pathway (1333181); Apoptotic Execution Phase Pathway (1333205); Programmed Cell Death Pathway (1333180); TNF Signaling Pathway (812267); TNF Signaling Pathway (813210)

ncbi summary :

human homolog is a GTPase that is necessary for peroxisome division [RGD, Feb 2006]

uniprot summary :

DRP1: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis- dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport. Homotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Can self-assemble in multimeric ring-like structures. Interacts with BCL2L1; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with FIS1. Interacts with GSK3B and MARCH5. Interacts (via the GTPase and B domains) with UBE2I; the interaction promotes sumoylation of DNM1L, mainly in ite B domain. Interacts with PPP3CA; the interaction dephosphorylates DNM1L and regulates its transition to mitochondria. Interacts witn MID49 and MID51. Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons. Belongs to the dynamin family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Microtubule-binding; Endoplasmic reticulum; Motor; Hydrolase; EC 3.6.5.5; Mitochondrial; Apoptosis. Cellular Component: brush border; cell junction; coated pit; cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; membrane; microtubule; microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion; perinuclear region of cytoplasm; peroxisome; protein complex; synaptic vesicle membrane. Molecular Function: GTP binding; GTPase activity; identical protein binding; lipid binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding. Biological Process: endocytosis; heart contraction; mitochondrial fission; mitochondrial fragmentation during apoptosis; peroxisome fission; positive regulation of apoptosis; positive regulation of protein secretion; protein homotetramerization; regulation of protein oligomerization; release of cytochrome c from mitochondria

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095