Human Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) ELISA Kit | MyBioSource MBS9357948 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) ELISA Kit

catalog :

MBS9357948

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9357948

products type :

ELISA Kit

products full name :

Human Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) ELISA Kit

products short name :

[Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A)]

other names :

[protein phosphatase 1 regulatory subunit 15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog]

products gene name :

[PPP1R15A]

other gene names :

[PPP1R15A; PPP1R15A; GADD34; GADD34]

uniprot entry name :

PR15A_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PPP1R15A (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

157674363

ncbi acc num :

NP_055145.3

ncbi gb acc num :

NM_014330.3

ncbi mol weight :

56,515 Da

ncbi pathways :

BMP Receptor Signaling Pathway (137948); Downregulation Of TGF-beta Receptor Signaling Pathway (1269525); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190); Signal Transduction Pathway (1269379); Signaling By TGF-beta Receptor Complex Pathway (1269523); TGF-beta Receptor Signaling Pathway (138024); TGF-beta Receptor Signaling Activates SMADs Pathway (1269524)

ncbi summary :

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

uniprot summary :

GADD34: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Belongs to the PPP1R15 family. Protein type: Apoptosis; DNA repair, damage; Translation initiation; Cell cycle regulation. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane; mitochondrial outer membrane; mitochondrion; protein phosphatase type 1 complex. Molecular Function: protein binding; protein kinase binding; protein phosphatase 1 binding; protein phosphatase type 1 regulator activity. Biological Process: aging; apoptosis; cell cycle arrest; negative regulation of cell proliferation; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein amino acid dephosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoprotein phosphatase activity; positive regulation of transcription from RNA polymerase I promoter; positive regulation of translation initiation in response to stress; regulation of angiogenesis; response to cocaine; response to DNA damage stimulus; transforming growth factor beta receptor signaling pathway; unfolded protein response

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095