Human cyclophilin B, CyPB ELISA Kit | MyBioSource MBS935501 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human cyclophilin B, CyPB ELISA Kit

catalog :

MBS935501

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS935501

products type :

ELISA Kit

products full name :

Human cyclophilin B, CyPB ELISA Kit

products short name :

peptidylprolyl isomerase B (cyclophilin B)

products name syn :

Human cyclophilin B; CyPB ELISA Kit; CYP-S1; CYPB; MGC14109; MGC2224; OI9; SCYLP; PPIase; S-cyclophilin; cyclophilin-like protein; peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; rotamase; peptidylprolyl isomerase B (cyclophilin B)

other names :

peptidyl-prolyl cis-trans isomerase B; Peptidyl-prolyl cis-trans isomerase B; peptidyl-prolyl cis-trans isomerase B; PPIase B; rotamase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory protein Li 39; peptidylprolyl isomerase B (cyclophilin B); CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP

products gene name :

PPIB

other gene names :

PPIB; PPIB; OI9; CYPB; SCYLP; CYP-S1; HEL-S-39; CYPB; PPIase B; SCYLP

uniprot entry name :

PPIB_HUMAN

reactivity :

Human

sequence length :

216

specificity :

This assay has high sensitivity and excellent specificity for detection of human CyPB. No significant cross-reactivity or interference between human CyPB and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, cell ell ell lysates ysates, tissue homogenates. Assay Type: Sandwich. Detection Range: 31.25 pg/ml -2000 pg/ml. Sensitivity: 7.8 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for CyPB has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any CyPB present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CyPB is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CyPB bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

4758950

ncbi acc num :

NP_000933.1

ncbi gb acc num :

NM_000942.4

uniprot acc num :

P23284

ncbi mol weight :

23,743 Da

ncbi pathways :

Syndecan-1-mediated Signaling Events Pathway (138046)

ncbi summary :

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

uniprot summary :

PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. Protein type: Secreted; Cyclophilin; RNA-binding; Chaperone; Secreted, signal peptide; EC 5.2.1.8; Isomerase. Chromosomal Location of Human Ortholog: 15q21-q22. Cellular Component: smooth endoplasmic reticulum; focal adhesion; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; endoplasmic reticulum lumen; melanosome; nucleus. Molecular Function: collagen binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; protein complex binding; peptide binding. Biological Process: extracellular matrix organization and biogenesis; protein peptidyl-prolyl isomerization; protein stabilization; positive regulation of multicellular organism growth. Disease: Osteogenesis Imperfecta, Type Ix

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage