catalog number :
MBS9354758
products type :
ELISA Kit
products full name :
Human Lens Fiber Major Intrinsic Protein (MIP) ELISA Kit
products short name :
[Lens Fiber Major Intrinsic Protein (MIP)]
other names :
[lens fiber major intrinsic protein; Lens fiber major intrinsic protein; lens fiber major intrinsic protein; major intrinsic protein of lens fiber; Aquaporin-0; MIP26; MP26]
products gene name :
[MIP]
other gene names :
[MIP; MIP; AQP0; LIM1; MP26; MIP26; CTRCT15; AQP0; MP26]
uniprot entry name :
MIP_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MIP (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_036196.1
ncbi gb acc num :
NM_012064.3
ncbi mol weight :
28,122 Da
ncbi pathways :
Aquaporin-mediated Transport Pathway (1269944); Passive Transport By Aquaporins Pathway (1269945); Transmembrane Transport Of Small Molecules Pathway (1269903)
ncbi summary :
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]
uniprot summary :
AQP0: major intrinsic protein of lens fiber. A member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. May be responsible for regulating the osmolarity of the lens. Defects in MIP are a cause of autosomal recessive congenital cataract. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Transporter, aquaporin family. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: apical plasma membrane; gap junction; integral to plasma membrane; intracellular canaliculus; intracellular membrane-bound organelle; plasma membrane. Molecular Function: calmodulin binding; glycerol channel activity; structural constituent of eye lens; transporter activity; water channel activity. Biological Process: canalicular bile acid transport; glycerol transport; lens development in camera-type eye; response to stimulus; transmembrane transport; visual perception; water transport. Disease: Cataract 15, Multiple Types
size4 :
10x96-Strip-Wells