catalog number :
MBS9353308
products type :
ELISA Kit
products full name :
Human Vitamin D3 Receptor (VDR) ELISA Kit
products short name :
[Vitamin D3 Receptor (VDR)]
other names :
[vitamin D3 receptor isoform VDRB1; Vitamin D3 receptor; vitamin D3 receptor; vitamin D (1,25- dihydroxyvitamin D3) receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1]
products gene name :
[VDR]
other gene names :
[VDR; VDR; NR1I1; PPP1R163; NR1I1; VDR]
uniprot entry name :
VDR_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 1.56 nmol/L - 50 nmol/L. Sensitivity: 0.1 nmol/L
other info2 :
Intra-assay Precision: Intra-assay CV(%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of VDR (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001017536.1
ncbi gb acc num :
NM_001017536.1
ncbi mol weight :
53,883 Da
ncbi pathways :
Direct P53 Effectors Pathway (137939); Drug Induction Of Bile Acid Pathway (698755); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Nuclear Receptor Transcription Pathway (1269652); Nuclear Receptors Pathway (198848)
ncbi summary :
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
uniprot summary :
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
size4 :
10x96-Strip-Wells