Human Niemann Pick C1 Like Protein 1 (NPC1L1) ELISA Kit | MyBioSource MBS9352476 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Niemann Pick C1 Like Protein 1 (NPC1L1) ELISA Kit

catalog :

MBS9352476

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9352476

products type :

ELISA Kit

products full name :

Human Niemann Pick C1 Like Protein 1 (NPC1L1) ELISA Kit

products short name :

[Niemann Pick C1 Like Protein 1 (NPC1L1)]

other names :

[Niemann-Pick C1-like protein 1 isoform 2; Niemann-Pick C1-like protein 1; Niemann-Pick C1-like protein 1; NPC1 like 1]

products gene name :

[NPC1L1]

other gene names :

[NPC1L1; NPC1L1; NPC11L1]

uniprot entry name :

NPCL1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NPC1L1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

156231353

ncbi acc num :

NP_001095118.1

ncbi gb acc num :

NM_001101648.1

ncbi mol weight :

140,420 Da

ncbi pathways :

Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Trafficking Of Dietary Sterols Pathway (1270004); Vitamin A And Carotenoid Metabolism Pathway (920901); Vitamin A And Carotenoid Metabolism Pathway (198785)

ncbi summary :

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

uniprot summary :

NPC1L1: Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion. Expression is decreased in Caco-2 cells upon PPARD activation. Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. Belongs to the patched family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7p13. Cellular Component: apical plasma membrane; brush border membrane; cytoplasmic vesicle membrane; integral to membrane; plasma membrane. Molecular Function: drug binding; hedgehog receptor activity; myosin V binding; protein binding; Rab GTPase binding. Biological Process: cholesterol absorption; cholesterol biosynthetic process; cholesterol homeostasis; cholesterol transport; lipoprotein metabolic process; response to drug; signal transduction; sterol transport

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095