ELISA/assay

Canine Myosin Light Chain 3 (MYL3) ELISA Kit

MBS9351024

48-Strip-Wells

470 USD

ELISA Kit

Canine Myosin Light Chain 3 (MYL3) ELISA Kit

[Myosin Light Chain 3 (MYL3)]

[myosin light chain 3; Myosin light chain 3; myosin light chain 3; myosin light chain 3; Cardiac myosin light chain 1]

[MYL3]

[MYL3; MYL3; CMH8; VLC1; VLCl; MLC1V; MLC1SB; MLC-lV/sb; MLC-lV/sb]

MYL3_HUMAN

Canine

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MYL3 (hereafter termed "analyte") in undiluted original Canine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

4557777

NP_000249.1

NM_000258.2

21,932 Da

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (1269868); Regulation Of Actin Cytoskeleton Pathway (198874)

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive. Protein type: Motility/polarity/chemotaxis; Motor. Chromosomal Location of Human Ortholog: 3p21.3-p21.2. Cellular Component: A band; cytosol; I band; muscle myosin complex; sarcomere. Molecular Function: actin monomer binding; calcium ion binding; motor activity; myosin II heavy chain binding; structural constituent of muscle. Biological Process: cardiac muscle contraction; metabolic process; muscle filament sliding; positive regulation of ATPase activity; regulation of striated muscle contraction; regulation of the force of heart contraction; skeletal muscle development; ventricular cardiac muscle morphogenesis. Disease: Cardiomyopathy, Familial Hypertrophic, 8

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095