catalog number :
MBS9349047
products type :
ELISA Kit
products full name :
Cavy Sodium Channel Protein Type 10 Subunit Alpha (SCN10A) ELISA Kit
products short name :
[Sodium Channel Protein Type 10 Subunit Alpha (SCN10A)]
other names :
[sodium channel protein type 10 subunit alpha isoform 2; Sodium channel protein type 10 subunit alpha; sodium channel protein type 10 subunit alpha; sodium voltage-gated channel alpha subunit 10; Peripheral nerve sodium channel 3; PN3; hPN3; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8]
products gene name :
[SCN10A]
other gene names :
[SCN10A; SCN10A; PN3; SNS; hPN3; FEPS2; Nav1.8; PN3; hPN3]
uniprot entry name :
SCNAA_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Cavy body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SCN10A (hereafter termed "analyte") in undiluted original Cavy body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001280235.2
ncbi gb acc num :
NM_001293306.2
ncbi mol weight :
220,626 Da
ncbi pathways :
Axon Guidance Pathway (1270303); Cardiac Conduction Pathway (1339115); Developmental Biology Pathway (1270302); Interaction Between L1 And Ankyrins Pathway (1270325); L1CAM Interactions Pathway (1270323); Muscle Contraction Pathway (1269868); Phase 0 - Rapid Depolarisation Pathway (1339117)
ncbi summary :
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
uniprot summary :
SCN10A: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Protein type: Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3p22.2. Cellular Component: voltage-gated sodium channel complex. Molecular Function: voltage-gated sodium channel activity. Biological Process: generation of action potential; odontogenesis of dentine-containing teeth; regulation of heart rate; sensory perception; sensory perception of pain. Disease: Episodic Pain Syndrome, Familial, 2
size4 :
10x96-Strip-Wells