Human Securin (PTTG1) ELISA Kit | MyBioSource MBS9343579 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Securin (PTTG1) ELISA Kit

catalog :

MBS9343579

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9343579

products type :

ELISA Kit

products full name :

Human Securin (PTTG1) ELISA Kit

products short name :

[Securin (PTTG1)]

other names :

[securin; Securin; securin; pituitary tumor-transforming 1; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG]

products gene name :

[PTTG1]

other gene names :

[PTTG1; PTTG1; EAP1; PTTG; HPTTG; TUTR1; EAP1; PTTG; TUTR1; Tumor-transforming protein 1; hPTTG]

uniprot entry name :

PTTG1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PTTG1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

538260594

ncbi acc num :

NP_001269312.1

ncbi gb acc num :

NM_001282383.1

ncbi mol weight :

22,024 Da

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (1269838); APC/C:Cdc20 Mediated Degradation Of Securin Pathway (1269849); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (1269844); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (1269851); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (1269842); Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463)

ncbi summary :

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

uniprot summary :

Securin: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family. Protein type: Cell cycle regulation; Oncoprotein. Chromosomal Location of Human Ortholog: 5q35.1. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: cysteine protease inhibitor activity; protease inhibitor activity; protein binding; SH3 domain binding; transcription factor activity. Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; chromosome organization and biogenesis; DNA repair; homologous chromosome segregation; mitosis; mitotic cell cycle; negative regulation of peptidase activity; regulation of transcription, DNA-dependent; spermatogenesis; transcription from RNA polymerase II promoter

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095