catalog number :
MBS9343390
products type :
ELISA Kit
products full name :
Rat Protein unc-13 homolog A, UNC13A ELISA Kit
products short name :
[unc-13 homolog A (C. elegans)]
products name syn :
[Rat Protein unc-13 homolog A (UNC13A) ELISA kit; KIAA1032; Munc13-1; unc-13 homolog A; unc-13 homolog A (C. elegans)]
other names :
[protein unc-13 homolog A; Protein unc-13 homolog A; protein unc-13 homolog A; unc-13 homolog A (C. elegans); Munc13-1]
products gene name :
[UNC13A]
other gene names :
[Unc13a; Unc13a; Unc13h1; Munc13-1; Unc13h1]
uniprot entry name :
UN13A_RAT
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of UNC13A (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_074052.1
ncbi gb acc num :
NM_022861.1
ncbi mol weight :
196,356 Da
ncbi pathways :
Synaptic Vesicle Cycle Pathway (373895); Synaptic Vesicle Cycle Pathway (373890)
ncbi summary :
brain specific protein that may have role during neurotransmitter release [RGD, Feb 2006]
uniprot summary :
UNC13A: involved in secretory granule priming in insulin secretion and vesicle maturation during exocytosis. A target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Interacts with RIMS1, BSN, DOC2A, and STX1A or STX1B1. Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester. Protein type: Membrane protein, peripheral. Cellular Component: presynaptic membrane; neuron projection; protein complex; axon; cytoplasm; terminal button; excitatory synapse; synapse; cell junction; neuromuscular junction. Molecular Function: diacylglycerol binding; protein domain specific binding; SNARE binding; protein homodimerization activity; protein heterodimerization activity; metal ion binding; syntaxin-1 binding; protein N-terminus binding. Biological Process: synaptic transmission, glutamatergic; synaptic vesicle maturation; beta-amyloid metabolic process; neurotransmitter secretion; regulation of short-term neuronal synaptic plasticity; synaptic vesicle priming; positive regulation of neurotransmitter secretion; neuromuscular junction development; synaptic vesicle docking during exocytosis
size4 :
10x96-Strip-Wells