Human Transforming growth factor beta-1-induced transcript 1 protein, TGFB1I1 ELISA Kit | MyBioSource MBS9343318 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Transforming growth factor beta-1-induced transcript 1 protein, TGFB1I1 ELISA Kit

catalog :

MBS9343318

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9343318

products type :

ELISA Kit

products full name :

Human Transforming growth factor beta-1-induced transcript 1 protein, TGFB1I1 ELISA Kit

products short name :

[transforming growth factor beta 1 induced transcript 1]

products name syn :

[Human Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) ELISA kit; ARA55; HIC-5; HIC5; TSC-5; androgen receptor coactivator ARA55; androgen receptor-associated protein of 55 kDa; hydrogen peroxide-inducible clone 5 protein; transforming growth factor beta 1 induced transcript 1]

other names :

[transforming growth factor beta-1-induced transcript 1 protein isoform 1; Transforming growth factor beta-1-induced transcript 1 protein; transforming growth factor beta-1-induced transcript 1 protein; androgen receptor coactivator ARA55; hydrogen peroxide-inducible clone 5 protein; androgen receptor coactivator 55 kDa protein; androgen receptor-associated protein of 55 kDa; transforming growth factor beta 1 induced transcript 1; Androgen receptor coactivator 55 kDa protein; Androgen receptor-associated protein of 55 kDa; Hydrogen peroxide-inducible clone 5 protein; Hic-5]

products gene name :

[TGFB1I1]

other gene names :

[TGFB1I1; TGFB1I1; HIC5; ARA55; HIC-5; TSC-5; ARA55; Hic-5]

uniprot entry name :

TGFI1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TGFB1I1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

109638745

ncbi acc num :

NP_001035919.1

ncbi gb acc num :

NM_001042454.2

uniprot acc num :

O43294

ncbi mol weight :

49,814 Da

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); Monoamine Transport Pathway (198851)

ncbi summary :

This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

uniprot summary :

Hic-5: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Up-regulated by TNF and hydrogen peroxide. Expressed in platelets, smooth muscle and prostate stromal cells. Belongs to the paxillin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: extracellular matrix; focal adhesion; cytoskeleton; nuclear matrix; cytoplasm; intracellular. Molecular Function: protein binding; Roundabout binding; androgen receptor binding; zinc ion binding; transcription coactivator activity. Biological Process: transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; cell fate commitment; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of fat cell differentiation; ubiquitin-dependent SMAD protein catabolic process; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; epithelial cell differentiation; response to heat; androgen receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; cell adhesion

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage