ELISA/assay

Human Multidrug resistance protein 3, ABCB4 ELISA Kit

MBS9343294

48-Strip-Wells

435 USD

ELISA Kit

Human Multidrug resistance protein 3, ABCB4 ELISA Kit

ATP-binding cassette, sub-family B (MDR/TAP) , member 4

Human Multidrug resistance protein 3 (ABCB4) ELISA kit; ABC21; GBD1; MDR2; MDR2/3; MDR3; PFIC-3; PGY3; ATP-binding cassette; subfamily B; member 4; OTTHUMP00000210458; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3; ; ATP-binding cassette; sub-family B (MDR/TAP); member 4

multidrug resistance protein 3 isoform A; Multidrug resistance protein 3; multidrug resistance protein 3; P-glycoprotein 3; multiple drug resistance 3; ATP-binding cassette sub-family B member 4; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette sub-family B member 4; P-glycoprotein 3

ABCB4

ABCB4; ABCB4; GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3; MDR3; PGY3

MDR3_HUMAN

Human

Store all reagents at 2-8 degree C

4505771

NP_000434.1

NM_000443.3

P21439

141,523 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described. Protein type: Hydrolase; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Membrane protein, integral; EC 3.6.3.44. Chromosomal Location of Human Ortholog: 7q21.1. Cellular Component: intercellular canaliculus; membrane; integral to plasma membrane; plasma membrane; integral to membrane. Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding; xenobiotic-transporting ATPase activity. Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; cellular lipid metabolic process; lipid metabolic process; transmembrane transport. Disease: Gallbladder Disease 1; Cholestasis, Progressive Familial Intrahepatic, 3; Cholestasis, Intrahepatic, Of Pregnancy 3

48-Strip-Wells

435 USD

96-Strip-Wells

600