Human Disrupted in schizophrenia 1 protein, DISC1 ELISA Kit | MyBioSource MBS9343138 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Disrupted in schizophrenia 1 protein, DISC1 ELISA Kit

catalog :

MBS9343138

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9343138

products type :

ELISA Kit

products full name :

Human Disrupted in schizophrenia 1 protein, DISC1 ELISA Kit

products short name :

[disrupted in schizophrenia 1]

products name syn :

[Human Disrupted in schizophrenia 1 protein (DISC1) ELISA kit; RP4-730B13.1; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9; ; disrupted in schizophrenia 1]

other names :

[disrupted in schizophrenia 1 protein isoform Lv; Disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1]

products gene name :

[DISC1]

other gene names :

[DISC1; DISC1; SCZD9; C1orf136; KIAA0457]

uniprot entry name :

DISC1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DISC1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

61742825

ncbi acc num :

NP_001012975.1

ncbi gb acc num :

NM_001012957.1

uniprot acc num :

Q9NRI5

ncbi mol weight :

93,611 Da

ncbi summary :

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

DISC1: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Cell development/differentiation; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q42.1. Cellular Component: postsynaptic membrane; microtubule; centrosome; mitochondrion; postsynaptic density; cell junction. Molecular Function: protein binding. Biological Process: positive regulation of neuroblast proliferation; mitochondrial calcium ion homeostasis; TOR signaling pathway; cell proliferation in forebrain; neuron migration; cerebral cortex radially oriented cell migration; Wnt receptor signaling pathway through beta-catenin; microtubule cytoskeleton organization and biogenesis; positive regulation of Wnt receptor signaling pathway. Disease: Schizophrenia; Schizophrenia 9

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage