catalog number :
MBS9343135
products type :
ELISA Kit
products full name :
Human Keratin, type I cytoskeletal 16, KRT16 ELISA Kit
products short name :
[keratin 16]
products name syn :
[Human Keratin; type I cytoskeletal 16 (KRT16) ELISA kit; CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK; cytokeratin 16; focal non-epidermolytic palmoplantar keratoderma; keratin; type I cytoskeletal 16; keratin 16]
other names :
[keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 16; keratin, type I cytoskeletal 16; CK-16; keratin-16; cytokeratin 16; cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma; keratin 16; Cytokeratin-16; CK-16; Keratin-16; K16]
products gene name :
[KRT16]
other gene names :
[KRT16; KRT16; K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A; KRT16A; CK-16; K16]
uniprot entry name :
K1C16_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of KRT16 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_005548.2
ncbi gb acc num :
NM_005557.3
ncbi mol weight :
51,268 Da
ncbi summary :
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
uniprot summary :
K16: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. K16 and K17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.2. Cellular Component: cytoskeleton; intermediate filament; nucleus. Molecular Function: protein binding; structural constituent of cytoskeleton. Biological Process: epidermis development; intermediate filament cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; keratinocyte migration; hair cycle; keratinocyte differentiation; cell proliferation; keratinization; morphogenesis of an epithelium; innate immune response; inflammatory response; negative regulation of cell migration; aging. Disease: Palmoplantar Keratoderma, Nonepidermolytic, Focal; Pachyonychia Congenita 1
size4 :
10x96-Strip-Wells