Human Epidermal growth factor receptor kinase substrate 8, EPS8 ELISA Kit | MyBioSource MBS9343062 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Epidermal growth factor receptor kinase substrate 8, EPS8 ELISA Kit

catalog :

MBS9343062

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9343062

products type :

ELISA Kit

products full name :

Human Epidermal growth factor receptor kinase substrate 8, EPS8 ELISA Kit

products short name :

[epidermal growth factor receptor pathway substrate 8]

products name syn :

[Human Epidermal growth factor receptor kinase substrate 8 (EPS8) ELISA kit; epidermal growth factor receptor pathway substrate 8]

other names :

[epidermal growth factor receptor kinase substrate 8; Epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor pathway substrate 8]

products gene name :

[EPS8]

other gene names :

[EPS8; EPS8]

uniprot entry name :

EPS8_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of EPS8 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

56682953

ncbi acc num :

NP_004438.3

ncbi gb acc num :

NM_004447.5

uniprot acc num :

Q12929

ncbi mol weight :

91,882 Da

ncbi pathways :

CDC42 Signaling Events Pathway (137994); EGFR1 Signaling Pathway (198782); ErbB1 Downstream Signaling Pathway (138057); Regulation Of RAC1 Activity Pathway (169346)

ncbi summary :

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

EPS8: an adaptor protein that is an epidermal growth factor receptor (EGFR) substrate. Enhances EGF-dependent mitogenic signals. Member of a family of actin barbing and capping proteins. Promotes filopodial protrusions. Complexes containing Eps8/Abi1/PI3K/Sos-1 mediate Rac activation following EGFR signaling. Involved in endocytosis of EGFR by binding to the Rab5-specific GTPase activating protein USP6N. Binds to IRSp53, which binds small the small GTPases Rac and Cdc42, and which regulates actin dynamics. Involved in the actin-remodeling activity in cultured cerebellar neurons. Regulates the actin-remodeling activities of NMDA and ethanol in neurons. Eps8 knockout mice show behavioral resistance to ethanol. Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 12p12.3. Cellular Component: stereocilium; growth cone; postsynaptic density; cell cortex; cell junction; vesicle; N-methyl-D-aspartate selective glutamate receptor complex. Molecular Function: protein binding; SH3/SH2 adaptor activity; Rac GTPase binding; actin binding. Biological Process: actin crosslink formation; epidermal growth factor receptor signaling pathway; actin filament bundle formation; positive regulation of signal transduction; adult locomotory behavior; Rac protein signal transduction; behavioral response to ethanol; signal transduction; regulation of cell shape; cell proliferation; actin cytoskeleton reorganization; regulation of actin filament length; barbed-end actin filament capping; exit from mitosis. Disease: Deafness, Autosomal Recessive 102

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage