ELISA/assay

Human N-acetylaspartate synthetase, NAT8L ELISA Kit

MBS9343002

48-Strip-Wells

435 USD

ELISA Kit

Human N-acetylaspartate synthetase, NAT8L ELISA Kit

N-acetyltransferase 8-like (GCN5-related, putative)

Human N-acetylaspartate synthetase (NAT8L) ELISA kit; CML3; FLJ37478; MGC117272; NAT8-LIKE; ; N-acetyltransferase 8-like (GCN5-related; putative)

N-acetylaspartate synthetase; N-acetylaspartate synthetase; N-acetylaspartate synthetase; NAA synthetase; camello-like protein 3; N-acetyltransferase 8-like (GCN5-related, putative); Camello-like protein 3; N-acetyltransferase 8-like protein

NAT8L

NAT8L; NAT8L; CML3; NACED; NAT8-LIKE; CML3; NAA synthetase

NAT8L_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NAT8L (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

263192221

NP_848652.2

NM_178557.3

Q8N9F0

32,837 Da

This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]

NAT8L: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED). A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. Belongs to the camello family. Protein type: Membrane protein, integral; Acetyltransferase; EC 2.3.1.17. Chromosomal Location of Human Ortholog: 4p16.3. Cellular Component: mitochondrion; mitochondrial membrane; cytoplasm; integral to membrane; rough endoplasmic reticulum membrane. Molecular Function: aspartate N-acetyltransferase activity. Biological Process: positive regulation of dopamine uptake; metabolic process. Disease: N-acetylaspartate Deficiency

48-Strip-Wells

435 USD

96-Strip-Wells

600