ELISA/assay

Human Semaphorin-6D, SEMA6D ELISA Kit

MBS9342837

48-Strip-Wells

470 USD

ELISA Kit

Human Semaphorin-6D, SEMA6D ELISA Kit

[sema domain, transmembrane domain (TM) , and cytoplasmic domain, (semaphorin) 6D]

[Human Semaphorin-6D (SEMA6D) ELISA kit; FLJ11598; KIAA1479; semaphorin 6D; sema domain; transmembrane domain (TM); and cytoplasmic domain; (semaphorin) 6D]

[semaphorin-6D isoform 1; Semaphorin-6D; semaphorin-6D; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D]

[SEMA6D]

[SEMA6D; SEMA6D; KIAA1479]

SEM6D_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SEMA6D (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

312222667

NP_001185928.1

NM_001198999.1

Q8NFY4

119,872 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Metabolism Of Proteins Pathway (106230); Other Semaphorin Interactions Pathway (119526); Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway (106236); Post-translational Protein Modification Pathway (161012); Semaphorin Interactions Pathway (119519); Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway (106238)

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

SEMA6D: a single-pass type I membrane protein of the semaphorin family that shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Seven alternatively spliced human isoforms have been reported. All are intrinsic membrane proteins except isoform 7, which is cytoplasmic. Protein type: Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: cytoplasm; plasma membrane; integral to membrane. Molecular Function: receptor activity; semaphorin receptor binding. Biological Process: axon guidance; ventricular system development; negative regulation of smooth muscle cell migration; positive regulation of smooth muscle cell migration

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095