Human Exosome complex exonuclease RRP44, DIS3 ELISA Kit | MyBioSource MBS9342350 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Exosome complex exonuclease RRP44, DIS3 ELISA Kit

catalog :

MBS9342350

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9342350

products type :

ELISA Kit

products full name :

Human Exosome complex exonuclease RRP44, DIS3 ELISA Kit

products short name :

[DIS3 mitotic control homolog (S. cerevisiae)]

products name syn :

[Human Exosome complex exonuclease RRP44 (DIS3) ELISA kit; DKFZp667L1817; EXOSC11; FLJ10484; KIAA1008; MGC33035; RP11-342J4.3; RRP44; bA555G22.1; dis3p; 2810028N01Rik; DIS3 mitotic control; exosome component 11; mitotic control protein dis3 homolog; DIS3 mitotic control homolog (S. cerevisiae)]

other names :

[exosome complex exonuclease RRP44 isoform b; Exosome complex exonuclease RRP44; exosome complex exonuclease RRP44; exosome component 11; DIS3 mitotic control homolog; ribosomal RNA-processing protein 44; mitotic control protein dis3 homolog; DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Protein DIS3 homolog; Ribosomal RNA-processing protein 44]

products gene name :

[DIS3]

other gene names :

[DIS3; DIS3; RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik; KIAA1008; RRP44]

uniprot entry name :

RRP44_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DIS3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

190014625

ncbi acc num :

NP_001121698.1

ncbi gb acc num :

NM_001128226.2

uniprot acc num :

Q9Y2L1

ncbi mol weight :

109,003 Da

ncbi pathways :

Activation Of Genes By ATF4 Pathway (530772); Deadenylation-dependent MRNA Decay Pathway (160993); Destabilization Of MRNA By Butyrate Response Factor 1 (BRF1) Pathway (187213); Destabilization Of MRNA By KSRP Pathway (187215); Destabilization Of MRNA By Tristetraprolin (TTP) Pathway (187214); Diabetes Pathways (105902); Disease Pathway (530764); Exosome, Eukaryotes Pathway (413457); Exosome, Eukaryotes Pathway (468397); Gene Expression Pathway (105937)

uniprot summary :

DIS3: Putative catalytic component of the RNA exosome complex which has 3 5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3 -5 exonuclease and endonuclease activities. Belongs to the RNR ribonuclease family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.26.-; EC 3.1.13.-; Ribonuclease; Nucleolus; G protein regulator, misc.; EC 3.1.13.-; RNA processing. Chromosomal Location of Human Ortholog: 13q22.1. Cellular Component: nucleoplasm; membrane; nucleolus; exosome (RNase complex); cytosol; nuclear exosome (RNase complex). Molecular Function: 3 -5 -exoribonuclease activity; protein binding; RNA binding; guanyl-nucleotide exchange factor activity; endonuclease activity. Biological Process: rRNA catabolic process; gene expression; rRNA processing; mRNA catabolic process, deadenylation-dependent decay; positive regulation of GTPase activity

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage