product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Histone-lysine N-methyltransferase, H3 lysine-79 specific, DOT1L ELISA Kit
catalog :
MBS9342121
quantity :
48-Strip-Wells
price :
470 USD
more info or order :
product information
catalog number :
MBS9342121
products type :
ELISA Kit
products full name :
Human Histone-lysine N-methyltransferase, H3 lysine-79 specific, DOT1L ELISA Kit
products short name :
[DOT1-like, histone H3 methyltransferase (S. cerevisiae)]
products name syn :
[Human Histone-lysine N-methyltransferase; H3 lysine-79 specific (DOT1L) ELISA kit; DKFZp586P1823; DOT1; KIAA1814; KMT4; DOT1-like; histone H3 methyltransferase; histone methyltransferase DOT1L; DOT1-like; histone H3 methyltransferase (S. cerevisiae)]
other names :
[histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone-lysine N-methyltransferase, H3 lysine-79 specific; histone-lysine N-methyltransferase, H3 lysine-79 specific; H3-K79-HMTase; DOT1-like protein; lysine N-methyltransferase 4; histone methyltransferase DOT1L; histone H3-K79 methyltransferase; DOT1-like, histone H3 methyltransferase; DOT1-like histone H3K79 methyltransferase; DOT1-like protein; Histone H3-K79 methyltransferase; H3-K79-HMTase; Lysine N-methyltransferase 4]
products gene name :
[DOT1L]
other gene names :
[DOT1L; DOT1L; DOT1; KMT4; KIAA1814; KMT4; H3-K79-HMTase]
uniprot entry name :
DOT1L_HUMAN
reactivity :
Human
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DOT1L (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi gi num :
22094135
ncbi acc num :
NP_115871.1
ncbi gb acc num :
NM_032482.2
uniprot acc num :
Q8TEK3
ncbi mol weight :
184,853 Da
ncbi pathways :
Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)
ncbi summary :
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
uniprot summary :
DOT1L: a protein methyltransferase that catalyzes the mono-, di- and tri-methylation of H3K79. Methylated H3K79 is associated with active gene transcription. DOT1L activity drives proliferation of mixed lineage leukemia 1 protein (MLL)-rearranged leukemias, inducing the aberrant transcription of a number of leukemogenic genes including HOXA9 and MEIS1. Binds to DNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.1.1.43; Methyltransferase, protein lysine; Methyltransferase; Amino Acid Metabolism - lysine degradation. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: nucleus. Molecular Function: protein binding; DNA binding; histone lysine N-methyltransferase activity (H3-K79 specific); histone-lysine N-methyltransferase activity; transcription factor binding. Biological Process: regulation of JAK-STAT cascade; regulation of cell cycle; chromatin silencing
size1 :
48-Strip-Wells
price1 :
470 USD
size2 :
96-Strip-Wells
price2 :
680
size3 :
5x96-Strip-Wells
price3 :
3100
size4 :
10x96-Strip-Wells
price4 :
6095
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
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