catalog number :
MBS9342059
products type :
ELISA Kit
products full name :
Human Anoctamin-3, ANO3 ELISA Kit
products short name :
[anoctamin 3]
products name syn :
[Human Anoctamin-3 (ANO3) ELISA kit; C11orf25; GENX-3947; TMEM16C; transmembrane protein 16C; transmembrane protein 16C (eight membrane-spanning domains) ; anoctamin 3]
other names :
[anoctamin-3; Anoctamin-3; anoctamin-3; transmembrane protein 16C (eight membrane-spanning domains); anoctamin 3; Transmembrane protein 16C]
products gene name :
[ANO3]
other gene names :
[ANO3; ANO3; DYT23; DYT24; TMEM16C; C11orf25; GENX-3947; C11orf25; TMEM16C; GENX-3947]
uniprot entry name :
ANO3_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ANO3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_113606.2
ncbi gb acc num :
NM_031418.2
ncbi mol weight :
114,657 Da
ncbi summary :
The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
uniprot summary :
ANO3: May act as a calcium-activated chloride channel. Belongs to the anoctamin family. Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p14.2. Cellular Component: plasma membrane; integral to membrane. Molecular Function: phospholipid scramblase activity; intracellular calcium activated chloride channel activity. Biological Process: lipid transport; transmembrane transport. Disease: Dystonia 24
size4 :
10x96-Strip-Wells