Human Roundabout homolog 2, ROBO2 ELISA Kit | MyBioSource MBS9341913 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Roundabout homolog 2, ROBO2 ELISA Kit

catalog :

MBS9341913

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9341913

products type :

ELISA Kit

products full name :

Human Roundabout homolog 2, ROBO2 ELISA Kit

products short name :

[roundabout, axon guidance receptor, homolog 2 (Drosophila)]

products name syn :

[Human Roundabout homolog 2 (ROBO2) ELISA kit; KIAA1568; SAX3; roundabout; axon guidance receptor; homolog 2; roundabout; axon guidance receptor; homolog 2 (Drosophila)]

other names :

[roundabout homolog 2 isoform ROBO2a; Roundabout homolog 2; roundabout homolog 2; roundabout, axon guidance receptor, homolog 2 (Drosophila)]

products gene name :

[ROBO2]

other gene names :

[ROBO2; ROBO2; SAX3; KIAA1568]

uniprot entry name :

ROBO2_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: The sensitivity of this kit is 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ROBO2 (hereafter termed this analyte) in undiluted original Human body fluids, tissue homogenates, secretions and feces samples.

ncbi gi num :

193083163

ncbi acc num :

NP_001122401.1

ncbi gb acc num :

NM_001128929.3

uniprot acc num :

Q9HCK4

ncbi mol weight :

151,200 Da

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Regulation Of Commissural Axon Pathfinding By Slit And Robo Pathway (119528); Signaling By Robo Receptor Pathway (119527)

ncbi summary :

The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

uniprot summary :

ROBO2: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2). VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults. A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT- ROBO signaling in vitro. Belongs to the immunoglobulin superfamily. ROBO family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell development/differentiation; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 3p12.3. Cellular Component: cell surface; integral to membrane; axolemma. Molecular Function: identical protein binding; protein binding; axon guidance receptor activity. Biological Process: axon guidance; central nervous system development; olfactory bulb interneuron development; negative regulation of synaptogenesis; axon midline choice point recognition; cellular response to hormone stimulus; negative regulation of negative chemotaxis; ureteric bud development; positive regulation of axonogenesis; brain development; homophilic cell adhesion; metanephros development; retinal ganglion cell axon guidance. Disease: Vesicoureteral Reflux 2

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095