Human Protein sprouty homolog 2, SPRY2 ELISA Kit | MyBioSource MBS9341632 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Protein sprouty homolog 2, SPRY2 ELISA Kit

catalog :

MBS9341632

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9341632

products type :

ELISA Kit

products full name :

Human Protein sprouty homolog 2, SPRY2 ELISA Kit

products short name :

sprouty homolog 2 (Drosophila)

products name syn :

Human Protein sprouty homolog 2 (SPRY2) ELISA kit; MGC23039; hSPRY2; OTTHUMP00000018544; sprouty 2; sprouty homolog 2 (Drosophila)

other names :

protein sprouty homolog 2; Protein sprouty homolog 2; protein sprouty homolog 2; spry-2; sprouty 2; sprouty homolog 2 (Drosophila)

products gene name :

SPRY2

other gene names :

SPRY2; SPRY2; hSPRY2; Spry-2

uniprot entry name :

SPY2_HUMAN

reactivity :

Human

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intended Uses: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SPRY2 (hereafter termed this analyte) in Human serum, plasma and tissue homogenate samples.

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SPRY2 (hereafter termed this analyte) in Human serum, plasma and tissue homogenate samples.

ncbi gi num :

5032115

ncbi acc num :

NP_005833.1

ncbi gb acc num :

NM_005842.2

uniprot acc num :

O43597

ncbi mol weight :

34,688 Da

ncbi pathways :

Disease Pathway (530764); EGFR Downregulation Pathway (106342); EGFR1 Signaling Pathway (198782); FGF Signaling Pathway (137989); Internalization Of ErbB1 Pathway (138013); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Negative Regulation Of FGFR Signaling Pathway (477118); Signal Transduction Pathway (477114); Signaling By EGFR Pathway (106337)

ncbi summary :

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

uniprot summary :

SPRY2: a feedback inhibitor of growth factor receptor signaling. Belongs to the sprouty family. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Protein type: Inhibitor; Adaptor/scaffold; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 13q31.1. Cellular Component: microtubule cytoskeleton; microtubule; plasma membrane; cytosol. Molecular Function: protein serine/threonine kinase inhibitor activity; protein serine/threonine kinase activator activity; protein binding; protein kinase binding. Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; cell fate commitment; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; negative regulation of cell proliferation; sensory perception of sound; establishment of mitotic spindle orientation; negative regulation of Ras protein signal transduction; negative regulation of apoptosis

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage