ELISA/assay

Human Paired box protein Pax-8 (PAX8) ELISA Kit

MBS9341150

48-Strip-Wells

470 USD

ELISA Kit

Human Paired box protein Pax-8 (PAX8) ELISA Kit

[Paired box protein Pax-8 (PAX8)]

[paired box 8; paired domain gene 8]

[paired box protein Pax-8 isoform PAX8A; Paired box protein Pax-8; paired box protein Pax-8; paired domain gene 8; paired box 8]

[PAX8]

[PAX8; PAX8]

PAX8_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PAX8 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

5803117

NP_003457.1

NM_003466.3

Q06710

48,218 Da

Id Signaling Pathway (198871); Pathways In Cancer (83105); Thyroid Cancer Pathway (83112); Thyroid Cancer Pathway (524); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

PAX8: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 2q13. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity. Biological Process: inner ear morphogenesis; anatomical structure morphogenesis; central nervous system development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; pronephros development; regulation of apoptosis; ureteric bud branching; thyroid gland development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; kidney development; urogenital system development. Disease: Hypothyroidism, Congenital, Nongoitrous, 2

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095