ELISA/assay

Human baculoviral IAP repeat-containing protein 2/3, BIRC2/3 ELISA Kit

MBS9340986

96 Strip Wells

600 USD

ELISA Kit

Human baculoviral IAP repeat-containing protein 2/3, BIRC2/3 ELISA Kit

baculoviral IAP repeat-containing protein 2/3 (BIRC2/3)

Human baculoviral IAP repeat-containing protein 2/3 (BIRC2/3) ELISA kit; BIRC2+3; c-IAP1+2; c-IAP1/2; cIAP1+2; cIAP1/2; cellular inhibitor of apoptosis 1/2; baculoviral IAP repeat-containing protein 2/3 (BIRC2/3)

baculoviral IAP repeat-containing protein 2 isoform 2; Baculoviral IAP repeat-containing protein 2; baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2; baculoviral IAP repeat containing 2; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2

BIRC2/3

BIRC2; BIRC2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; API1; IAP2; MIHB; RNF48; IAP-2; hIAP-2; hIAP2

BIRC2_HUMAN

Human

390608639

NP_001243095.1

NM_001256166.1

Q13490

64,098 Da

Apoptosis Pathway 198797!!Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!CD40/CD40L Signaling Pathway 138061!!Canonical NF-kappaB Pathway 138030!!Caspase Cascade In Apoptosis Pathway 137974!!FAS (CD95) Signaling Pathway 138081

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.6 PublicationsManual assertion based on experiment in:Ref.8. Enzyme regulation: The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination.2 PublicationsManual assertion based on experiment in:Ref.18

96 Strip Wells

600 USD