ELISA/assay

Human Zinc finger and BTB domain-containing protein 16, ZBTB16 ELISA Kit

MBS9340897

48-Strip-Wells

470 USD

ELISA Kit

Human Zinc finger and BTB domain-containing protein 16, ZBTB16 ELISA Kit

[zinc finger and BTB domain containing 16]

[Human Zinc finger and BTB domain-containing protein 16 (ZBTB16) ELISA kit; PLZF; ZNF145; promyelocytic leukemia zinc finger protein; zinc finger protein 145 (Kruppel-like; expressed in promyelocytic leukemia) ; zinc finger and BTB domain containing 16]

[zinc finger and BTB domain-containing protein 16; Zinc finger and BTB domain-containing protein 16; zinc finger and BTB domain-containing protein 16; zinc finger protein PLZF; promyelocytic leukaemia zinc finger; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); zinc finger and BTB domain containing 16; Promyelocytic leukemia zinc finger protein; Zinc finger protein 145; Zinc finger protein PLZF]

[ZBTB16]

[ZBTB16; ZBTB16; PLZF; ZNF145; PLZF; ZNF145]

ZBT16_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ZBTB16 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

66932932

NP_001018011.1

NM_001018011.1

Q05516

74,274 Da

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Immune System Pathway (106386); Pathways In Cancer (83105); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

PLZF: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Defects in ZBTB16 are the cause of skeletal defects genital hypoplasia and mental retardation (SGYMR). A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia. A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oncoprotein; Transcription, coactivator/corepressor; DNA-binding; C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 11q23.1. Cellular Component: nuclear body; PML body; transcriptional repressor complex; plasma membrane; nucleolus; nuclear speck; nucleus; cytosol. Molecular Function: protein C-terminus binding; identical protein binding; protein domain specific binding; protein binding; protein homodimerization activity; DNA binding; metal ion binding; double-stranded DNA binding. Biological Process: central nervous system development; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; positive regulation of transcription, DNA-dependent; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; embryonic hindlimb morphogenesis; positive regulation of ossification; anterior/posterior pattern formation; forelimb morphogenesis; negative regulation of cell proliferation; positive regulation of chondrocyte differentiation; cartilage development; positive regulation of fat cell differentiation; myeloid cell differentiation; hemopoiesis; mesonephros development; positive regulation of NK T cell differentiation; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; male germ-line stem cell division. Disease: Skeletal Defects, Genital Hypoplasia, And Mental Retardation

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095