ELISA/assay

Mouse Nuclear receptor subfamily 1 group D member 1, NR1D1 ELISA Kit

MBS9340203

48-Strip-Wells

470 USD

ELISA Kit

Mouse Nuclear receptor subfamily 1 group D member 1, NR1D1 ELISA Kit

[nuclear receptor subfamily 1, group D, member 1]

[Mouse Nuclear receptor subfamily 1 group D member 1 (NR1D1) ELISA kit; EAR1; THRA1; THRAL; ear-1; hRev; Rev-ErbAalpha; thyroid hormone receptor; alpha-like; nuclear receptor subfamily 1; group D; member 1]

[nuclear receptor subfamily 1 group D member 1; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1 group D member 1; EAR-1; REV-ERBalpha; rev-erb alpha; rev-erbA alpha; rev-erbA(alpha); Rev-ErbA-alpha protein; orphan nuclear receptor; V-erbA-related protein 1; nuclear receptor protein; nuclear receptor subfamily 1, group D, member 1; Rev-erbA-alpha; V-erbA-related protein 1; EAR-1]

[NR1D1]

[Nr1d1; Nr1d1; R75201; A530070C09Rik; Ear1; EAR-1]

NR1D1_MOUSE

Mouse

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/mL. Sensitivity: 10 pg/mL

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NR1D1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

110625908

NP_663409.2

NM_145434.4

Q3UV55

66,802 Da

Circadian Clock Pathway (575051); Circadian Exercise Pathway (198298); Circadian Repression Of Expression By REV-ERBA Pathway (575052); Circadian Rhythm - Mammal Pathway (83281); Circadian Rhythm - Mammal Pathway (495); Gene Expression Pathway (574654); Generic Transcription Pathway (574655); Nuclear Receptor Transcription Pathway (574657); RORA Activates Circadian Expression Pathway (575053)

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]

NR1D1: a widely expressed member of the orphan nuclear receptor family of proteins. Expressed at relatively high levels in adipose tissue, skeletal muscle, brain and liver, and regulates cellular proliferation and differentiation. Expression increases during differentiation in adipocytes and its ectopic expression in 3T3-L1 cells potentiates adipocyte differentiation. A metabolic regulator whose expression is increased in HER2-positive breast cancer cells. Regulates malate dehydrogenase 1 (MDH1) and malic enzyme 1 (ME1), enzymes that link glycolysis and fatty acid synthesis. May contribute to the abnormal cellular energy metabolism observed in HER2-positive breast cancers. Its expression oscillates with circadian rhythm in liver cells, regulating the expression of BMAL1, ApoA1 and ApoC3, all key regulators of circadian rhythm. Represses the basal activity of the mouse Bmal1 gene promoter. Phosphorylation by GSK3b at S55/59 stabilizes NRD1 protein levels. Regulates inflammation by targeting the NF-??B responsive genes IL-6 and COX-2. NR1D1 lacks the activation function 2 domain required for ligand-dependent activation of transcription by other members of the nuclear receptor family; thus it behaves as a constitutive repressor protein, recruiting the nuclear receptor co-repressor N-CoR1/HDAC3 complex to target genes to repress transcription. Protein type: Transcription factor; Nuclear receptor. Cellular Component: cell projection; nuclear chromatin; dendrite; cytoplasm; dendritic spine; nucleus. Molecular Function: protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding; heme binding; steroid hormone receptor activity; transcription factor activity. Biological Process: proteasomal protein catabolic process; circadian rhythm; transcription from RNA polymerase II promoter; circadian thermoregulation; glycogen biosynthetic process; regulation of lipid metabolic process; transcription, DNA-dependent; regulation of fat cell differentiation; positive regulation of transcription, DNA-dependent; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; regulation of transcription, DNA-dependent; negative regulation of toll-like receptor 4 signaling pathway; steroid hormone mediated signaling; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; cell differentiation

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095