ELISA/assay

Human Muscleblind-like protein 2, MBNL2 ELISA Kit

MBS9339994

48-Strip-Wells

470 USD

ELISA Kit

Human Muscleblind-like protein 2, MBNL2 ELISA Kit

[muscleblind-like 2 (Drosophila)]

[Human Muscleblind-like protein 2 (MBNL2) ELISA kit; RP11-128N14.1; DKFZp781H1296; MBLL; MBLL39; MGC120625; MGC120626; MGC120628; PRO2032; OTTHUMP00000178763; muscleblind-like 2; muscleblind-like 2 (Drosophila)]

[muscleblind-like protein 2 isoform 1; Muscleblind-like protein 2; muscleblind-like protein 2; muscleblind-like 2; muscleblind-like protein 1; muscleblind-like protein-like 39; muscleblind-like splicing regulator 2; Muscleblind-like protein 1; Muscleblind-like protein-like; Muscleblind-like protein-like 39]

[MBNL2]

[MBNL2; MBNL2; MBLL; MBLL39; PRO2032; MBLL; MBLL39; MLP1]

MBNL2_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 3.12ng/ml-100ng/ml. Sensitivity: 1.0ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of MBNL1 (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

21464125

NP_659002.1

NM_144778.3

Q5VZF2

40,518 Da

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]

MBNL2: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5 ACACCC-3 core sequence, termed zipcode, within the 3 UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). Belongs to the muscleblind family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 13q32.1. Cellular Component: cytoplasm; nucleus. Molecular Function: metal ion binding. Biological Process: regulation of RNA splicing; RNA splicing; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095