catalog number :
MBS9339877
products type :
ELISA Kit
products full name :
Human NKG2D ligand 1, ULBP1 ELISA Kit
products short name :
[UL16 binding protein 1]
products name syn :
[Human NKG2D ligand 1 (ULBP1) ELISA kit; RAET1I; OTTHUMP00000017410; alcan-beta; UL16 binding protein 1]
other names :
[NKG2D ligand 1; NKG2D ligand 1; NKG2D ligand 1; N2DL-1; NKG2DL1; alcan-beta; UL16-binding protein 1; retinoic acid early transcript 1I; UL16 binding protein 1; ALCAN-beta; Retinoic acid early transcript 1I; UL16-binding protein 1]
products gene name :
[ULBP1]
other gene names :
[ULBP1; ULBP1; RAET1I; N2DL1; RAET1I; N2DL-1; NKG2DL1]
uniprot entry name :
N2DL1_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ULBP1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_079494.1
ncbi gb acc num :
NM_025218.2
ncbi mol weight :
27,997 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Natural Killer Cell Mediated Cytotoxicity Pathway (83079); Natural Killer Cell Mediated Cytotoxicity Pathway (490)
uniprot summary :
ULBP1: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface. Belongs to the MHC class I family. Protein type: Membrane protein, GPI anchor; Apoptosis; Cell surface. Chromosomal Location of Human Ortholog: 6q25. Cellular Component: anchored to plasma membrane; endoplasmic reticulum; plasma membrane. Molecular Function: peptide antigen binding; natural killer cell lectin-like receptor binding. Biological Process: regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; natural killer cell mediated cytotoxicity; natural killer cell activation
size4 :
10x96-Strip-Wells