ELISA/assay

Human Tumor protein p53-inducible nuclear protein 1, TP53INP1 ELISA Kit

MBS9339342

48-Strip-Wells

470 USD

ELISA Kit

Human Tumor protein p53-inducible nuclear protein 1, TP53INP1 ELISA Kit

[tumor protein p53 inducible nuclear protein 1]

[Human Tumor protein p53-inducible nuclear protein 1 (TP53INP1) ELISA kit; DKFZp434M1317; FLJ22139; SIP; TP53DINP1; TP53INP1A; TP53INP1B; Teap; p53DINP1; p53-inducible p53DINP1; tumor protein p53 inducible nuclear protein 1]

[tumor protein p53-inducible nuclear protein 1 isoform b; Tumor protein p53-inducible nuclear protein 1; tumor protein p53-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; p53-dependent damage-inducible nuclear protein 1; tumor protein p53 inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1]

[TP53INP1]

[TP53INP1; TP53INP1; SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B; P53DINP1; SIP; p53DINP1]

T53I1_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TP53INP1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

209180469

NP_001129205.1

NM_001135733.1

Q96A56

27,366 Da

Direct P53 Effectors Pathway (137939); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889)

TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Cell cycle regulation; Tumor suppressor. Chromosomal Location of Human Ortholog: 8q22. Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; cytosol; nucleus. Molecular Function: antioxidant activity; protein binding. Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; apoptosis; response to heat; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095