Human Peroxisomal acyl-coenzyme A oxidase 1, ACOX1 ELISA Kit | MyBioSource MBS9339290 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Peroxisomal acyl-coenzyme A oxidase 1, ACOX1 ELISA Kit

catalog :

MBS9339290

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9339290

products type :

ELISA Kit

products full name :

Human Peroxisomal acyl-coenzyme A oxidase 1, ACOX1 ELISA Kit

products short name :

[acyl-Coenzyme A oxidase 1, palmitoyl]

products name syn :

[Human Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) ELISA kit; ACOX; MGC1198; PALMCOX; SCOX; acyl-CoA oxidase; straight-chain; acyl-Coenzyme A oxidase 1; peroxisomal fatty acyl-CoA oxidase; acyl-Coenzyme A oxidase 1; palmitoyl]

other names :

[peroxisomal acyl-coenzyme A oxidase 1 isoform c; Peroxisomal acyl-coenzyme A oxidase 1; peroxisomal acyl-coenzyme A oxidase 1; AOX; palmitoyl-CoA oxidase; straight-chain acyl-CoA oxidase; acyl-CoA oxidase, straight-chain; peroxisomal fatty acyl-CoA oxidase; acyl-Coenzyme A oxidase 1, palmitoyl; acyl-CoA oxidase 1, palmitoyl; Palmitoyl-CoA oxidase; Straight-chain acyl-CoA oxidase; SCOX]

products gene name :

[ACOX1]

other gene names :

[ACOX1; ACOX1; ACOX; SCOX; PALMCOX; ACOX; AOX; SCOX]

uniprot entry name :

ACOX1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ACOX1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

297206874

ncbi acc num :

NP_001171968.1

ncbi gb acc num :

NM_001185039.1

uniprot acc num :

Q15067

ncbi mol weight :

74,424 Da

ncbi pathways :

Beta-oxidation Of Very Long Chain Fatty Acids Pathway (106139); Biosynthesis Of Unsaturated Fatty Acids Pathway (83034); Biosynthesis Of Unsaturated Fatty Acids Pathway (429); Fatty Acid Metabolism Pathway (82935); Fatty Acid Metabolism Pathway (296); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450)

ncbi summary :

The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

ACOX1: Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD); also known as peroxisomal acyl-CoA oxidase deficiency. Pseudo-NALD is a peroxisomal single-enzyme disorder. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly, hearing deficit. Pseudo-NALD is characterized by increased plasma levels of very-long chain fatty cids, due to decreased or absent peroxisome acyl-CoA oxidase activity. Peroxisomes are intact and functioning. Belongs to the acyl-CoA oxidase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - alpha-linolenic acid; EC 1.3.3.6; Oxidoreductase; Lipid Metabolism - fatty acid; Lipid Metabolism - unsaturated fatty acid biosynthesis. Chromosomal Location of Human Ortholog: 17q25.1. Cellular Component: nucleoplasm; peroxisomal membrane; peroxisomal matrix; mitochondrion; intracellular membrane-bound organelle; membrane; plasma membrane; nucleolus; peroxisome; nucleus. Molecular Function: palmitoyl-CoA oxidase activity; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; FAD binding; protein N-terminus binding; fatty acid binding; PDZ domain binding; receptor binding. Biological Process: peroxisome fission; fatty acid beta-oxidation using acyl-CoA oxidase; generation of precursor metabolites and energy; very-long-chain fatty acid metabolic process; unsaturated fatty acid metabolic process; lipid homeostasis; spermatogenesis; fatty acid oxidation; lipid metabolic process; cellular lipid metabolic process; prostaglandin metabolic process. Disease: Peroxisomal Acyl-coa Oxidase Deficiency

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage