catalog number :
MBS9338850
products type :
ELISA Kit
products full name :
Human Transmembrane prostate androgen-induced protein, PMEPA1 ELISA Kit
products short name :
[prostate transmembrane protein, androgen induced 1]
products name syn :
[Human Transmembrane prostate androgen-induced protein (PMEPA1) ELISA kit; STAG1; TMEPAI; OTTHUMP00000174284; solid tumor-associated 1 protein; transmembrane prostate androgen-induced protein; transmembrane; prostate androgen induced RNA; prostate transmembrane protein; androgen induced 1]
other names :
[transmembrane prostate androgen-induced protein isoform d; Transmembrane prostate androgen-induced protein; transmembrane prostate androgen-induced protein; solid tumor-associated 1 protein; transmembrane, prostate androgen induced RNA; prostate transmembrane protein, androgen induced 1; Solid tumor-associated 1 protein]
products gene name :
[PMEPA1]
other gene names :
[PMEPA1; PMEPA1; STAG1; TMEPAI; STAG1; TMEPAI]
uniprot entry name :
PMEPA_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PMEPA1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001242905.1
ncbi gb acc num :
NM_001255976.1
ncbi mol weight :
31,609 Da
ncbi pathways :
Downregulation Of TGF-beta Receptor Signaling Pathway (645293); Signal Transduction Pathway (477114); Signaling By TGF-beta Receptor Complex Pathway (106504); TGF-beta Receptor Signaling Activates SMADs Pathway (645292)
ncbi summary :
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
uniprot summary :
TMEPAI: Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. Belongs to the PMEPA1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 20q13.31-q13.33. Cellular Component: Golgi membrane; early endosome membrane; plasma membrane; integral to membrane; endosome membrane. Molecular Function: protein binding; WW domain binding. Biological Process: transforming growth factor beta receptor signaling pathway; androgen receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway
size4 :
10x96-Strip-Wells