ELISA/assay

Human Disks large homolog 4, DLG4 ELISA Kit

MBS9338422

48-Strip-Wells

470 USD

ELISA Kit

Human Disks large homolog 4, DLG4 ELISA Kit

[discs, large homolog 4 (Drosophila)]

[Human Disks large homolog 4 (DLG4) ELISA kit; FLJ97752; FLJ98574; PSD95; SAP-90; SAP90; Tax interaction protein 15; discs large homolog 4; post-synaptic density protein 95; synapse-associated protein 90; discs; large homolog 4 (Drosophila)]

[disks large homolog 4 isoform 2; Disks large homolog 4; disks large homolog 4; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95; discs, large homolog 4 (Drosophila); Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90]

[DLG4]

[DLG4; DLG4; PSD95; SAP90; SAP-90; PSD95; PSD-95; SAP-90; SAP90]

DLG4_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DLG4 (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

192447426

NP_001122299.1

NM_001128827.1

P78352

80,495 Da

Activation Of Ca-permeable Kainate Receptor Pathway (161046); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (161043); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Axon Guidance Pathway (105688); CREB Phosphorylation Through The Activation Of CaMKII Pathway (161040); CREB Phosphorylation Through The Activation Of Ras Pathway (161036); Cocaine Addiction Pathway (546258); Cocaine Addiction Pathway (546273); Developmental Biology Pathway (477129); ErbB4 Signaling Events Pathway (137991)

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PSD-95: a membrane associated guanylate kinase (MAGUK) scaffolding protein located in neural postsynaptic densities. Associates with NMDA receptor NR2 subunits via glutamate serine (aspartate/glutamate) valine motifs in the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Its overexpression or depletion changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. Binds tissue-type plasminogen activator (tPA), mediating neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. Interacts through its first two PDZ domains with NMDAR2A, NMDAR2B, NMDAR2C, NMDAR2D, ACCN3, certain splice forms of NMDAR1, KV4.2, CXADR and synGAP. Interacts through its first two PDZ domains with Kv1.1, Kv1.2, Kv1.3, Kv1.4 and HER4. Interacts through its first PDZ domain with GluR6 and Kv1.4. Interacts through its second PDZ domain with the PDZ domain of nNOS or the C-terminus of NOS1AP. May interact with 5-HT(2A). Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with SAPAP1, SAPAP2, SAPAP3, SAPAP4, MAP1A, and BEGAIN. Interacts through its guanylate kinase-like domain with KIF13B. Two alternatively spliced human isoforms have been reported. Palmitoylation of isoform 1 is required for targeting to postsynaptic density. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: dendrite cytoplasm; cortical cytoskeleton; voltage-gated potassium channel complex; endoplasmic reticulum; basolateral plasma membrane; postsynaptic density; dendritic spine; excitatory synapse; postsynaptic membrane; synaptic vesicle; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; ionotropic glutamate receptor complex; synapse; cell junction. Molecular Function: protein C-terminus binding; P2Y1 nucleotide receptor binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding; beta-1 adrenergic receptor binding; acetylcholine receptor binding; protein complex binding; D1 dopamine receptor binding; protein phosphatase binding; PDZ domain binding. Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; nervous system development; synaptic vesicle maturation; learning; social behavior; signal transduction; positive regulation of synaptic transmission; establishment and/or maintenance of epithelial cell polarity; synaptic transmission; elevation of cytosolic calcium ion concentration; establishment of protein localization; protein complex assembly; neuromuscular process controlling balance; negative regulation of receptor internalization; nucleotide phosphorylation

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095