catalog number :
MBS9338411
products type :
ELISA Kit
products full name :
Human Xylosyltransferase 1, XYLT1 ELISA Kit
products short name :
xylosyltransferase I
products name syn :
Human Xylosyltransferase 1 (XYLT1) ELISA kit; PXYLT1; XT-I; XT1; XTI; XYLTI; O-xylosyltransferase 1; beta-D-xylosyltransferase 1; xylosyltransferase iota; xylosyltransferase I
other names :
xylosyltransferase 1; Xylosyltransferase 1; xylosyltransferase 1; xylT-I; O-xylosyltransferase 1; xylosyltransferase iota; beta-D-xylosyltransferase 1; peptide O-xylosyltransferase 1; xylosyltransferase I; Peptide O-xylosyltransferase 1; Xylosyltransferase I; XT-I; XylT-I
products gene name :
XYLT1
other gene names :
XYLT1; XYLT1; XT1; XTI; XT-I; DBQD2; XYLTI; PXYLT1; XT1; XT-I; XylT-I
uniprot entry name :
XYLT1_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of XYLT1 (hereafter termed this analyte) in Human serum, plasma and tissue homogenate samples.
ncbi acc num :
NP_071449.1
ncbi gb acc num :
NM_022166.3
ncbi mol weight :
107,569 Da
ncbi pathways :
Glycosaminoglycan Biosynthesis - Chondroitin Sulfate Pathway (82982); Glycosaminoglycan Biosynthesis - Chondroitin Sulfate Pathway (356); Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway (82984); Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway (358); Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway (413363); Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway (468250); Chondroitin Sulfate Biosynthesis Pathway (545279); Chondroitin Sulfate Biosynthesis Pathway (545411); Dermatan Sulfate Biosynthesis Pathway (545280); Dermatan Sulfate Biosynthesis Pathway (545412)
ncbi summary :
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]
uniprot summary :
XYLT1: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Belongs to the glycosyltransferase 14 family. XylT subfamily. Protein type: EC 2.4.2.26; Glycan Metabolism - heparan sulfate biosynthesis; Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p12.3. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; extracellular region; integral to membrane. Molecular Function: acetylglucosaminyltransferase activity; protein xylosyltransferase activity. Biological Process: glycosaminoglycan biosynthetic process; chondroitin sulfate biosynthetic process; heparan sulfate proteoglycan biosynthetic process. Disease: Desbuquois Dysplasia 2; Pseudoxanthoma Elasticum