Human Lysine-specific demethylase 2B, KDM2B ELISA Kit | MyBioSource MBS9337541 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Lysine-specific demethylase 2B, KDM2B ELISA Kit

catalog :

MBS9337541

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9337541

products type :

ELISA Kit

products full name :

Human Lysine-specific demethylase 2B, KDM2B ELISA Kit

products short name :

[lysine (K) -specific demethylase 2B]

products name syn :

[Human Lysine-specific demethylase 2B (KDM2B) ELISA kit; CXXC2; FBXL10; Fbl10; JHDM1B; PCCX2; F-box and leucine-rich repeat protein 10; JEMMA (Jumonji domain; EMSY-interactor; methyltransferase motif) protein; jumonji C domain-containing histone demethylase; lysine (K) -specific demethylase 2B]

other names :

[lysine-specific demethylase 2B isoform b; Lysine-specific demethylase 2B; lysine-specific demethylase 2B; F-box protein FBL10; F-box/LRR-repeat protein 10; CXXC-type zinc finger protein 2; protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B; F-box and leucine-rich repeat protein 10; jumonji C domain-containing histone demethylase 1B; jmjC domain-containing histone demethylation protein 1B; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; lysine (K)-specific demethylase 2B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein JEMMA; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B]

products gene name :

[KDM2B]

other gene names :

[KDM2B; KDM2B; CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2; Protein JEMMA]

uniprot entry name :

KDM2B_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of KDM2B (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

54112380

ncbi acc num :

NP_001005366.1

ncbi gb acc num :

NM_001005366.1

uniprot acc num :

Q8NHM5

ncbi mol weight :

152,615 Da

ncbi summary :

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

FBXL10: Histone demethylase that demethylates Lys-4 and Lys- 36 of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 Lys-4 and dimethylated H3 Lys-36 residue while it has weak or no activity for mono- and tri-methylated H3 Lys-36 . Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; DNA-binding; EC 1.14.11.27; Nucleolus; Demethylase. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: nucleoplasm; nucleolus; PcG protein complex; nucleus. Molecular Function: rRNA binding; protein binding; histone demethylase activity; DNA binding; zinc ion binding; histone demethylase activity (H3-K36 specific). Biological Process: midbrain-hindbrain boundary morphogenesis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; fourth ventricle development; negative regulation of transcription from RNA polymerase II promoter; third ventricle development; initiation of neural tube closure; histone demethylation; midbrain development; forebrain development; spermatogenesis; negative regulation of neuron apoptosis; embryonic camera-type eye morphogenesis; lateral ventricle development; hindbrain development

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage