Human MAP kinase-interacting serine/threonine-protein kinase 2, MKNK2 ELISA Kit | MyBioSource MBS9337428 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human MAP kinase-interacting serine/threonine-protein kinase 2, MKNK2 ELISA Kit

catalog :

MBS9337428

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9337428

products type :

ELISA Kit

products full name :

Human MAP kinase-interacting serine/threonine-protein kinase 2, MKNK2 ELISA Kit

products short name :

[MAP kinase interacting serine/threonine kinase 2]

products name syn :

[Human MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) ELISA kit; GPRK7; MNK2; G protein-coupled receptor kinase 7; MAP kinase-interacting serine/threonine kinase 2; Putative map kinase interacting kinase; MAP kinase interacting serine/threonine kinase 2]

other names :

[MAP kinase-interacting serine/threonine-protein kinase 2 isoform 1; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAPK signal-integrating kinase 2; G protein-coupled receptor kinase 7; MAP kinase signal-integrating kinase 2; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2]

products gene name :

[MKNK2]

other gene names :

[MKNK2; MKNK2; MNK2; GPRK7; GPRK7; MNK2; MAPK signal-integrating kinase 2; Mnk2]

uniprot entry name :

MKNK2_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MKNK2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

40018631

ncbi acc num :

NP_060042.2

ncbi gb acc num :

NM_017572.3

uniprot acc num :

Q9HBH9

ncbi mol weight :

51,875 Da

ncbi pathways :

Insulin Signaling Pathway (83090); Insulin Signaling Pathway (501); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456)

ncbi summary :

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

uniprot summary :

Mnk2: a ubiquituous CAM kinase of the MAPKKAPK family. Regulates translation by phosphorylating S209 of eIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. The phosphorylation of eIF4E S209 by the MNK1/2 kinases is required for eIF4E s oncogenic action. Phosphorylates Spry2 on S112 and S121, leading to the ubiquitination and degradation of Spry2. Five splice-variant isoforms have been described. Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation; Kinase, protein; EC 2.7.11.1; CAMK group; MAPKAPK family; MNK subfamily. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: nucleoplasm; PML body; cytoplasm; nucleolus; nucleus. Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding. Biological Process: regulation of translation; cell surface receptor linked signal transduction; hemopoiesis; protein amino acid phosphorylation

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage