Human Desmoplakin, DSP ELISA Kit | MyBioSource MBS9337331 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Desmoplakin, DSP ELISA Kit

catalog :

MBS9337331

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9337331

products type :

ELISA Kit

products full name :

Human Desmoplakin, DSP ELISA Kit

products short name :

[desmoplakin]

products name syn :

[Human Desmoplakin (DSP) ELISA kit; DPI; DPII; 250/210 kDa paraneoplastic pemphigus antigen; desmoplakin I; desmoplakin II; desmoplakin]

other names :

[desmoplakin isoform II; Desmoplakin; desmoplakin; desmoplakin I; desmoplakin II; 250/210 kDa paraneoplastic pemphigus antigen; desmoplakin; 250/210 kDa paraneoplastic pemphigus antigen]

products gene name :

[DSP]

other gene names :

[DSP; DSP; DP; DPI; DPII; DP]

uniprot entry name :

DESP_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Mouse Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 6.25ng/ml-200ng/ml. Sensitivity: 1.0ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of DSEL (hereafter termed "analyte") in undiluted original Mouse body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

58530842

ncbi acc num :

NP_001008844.1

ncbi gb acc num :

NM_001008844.1

uniprot acc num :

P15924

ncbi mol weight :

331,774 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129)

ncbi summary :

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

uniprot summary :

Desmoplakin: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 6p24. Cellular Component: desmosome; mitochondrion; basolateral plasma membrane; plasma membrane; cornified envelope; intermediate filament; fascia adherens; nucleus. Molecular Function: protein binding, bridging; protein binding; protein kinase C binding; structural constituent of cytoskeleton; cell adhesion molecule binding; structural molecule activity. Biological Process: keratinocyte differentiation; epidermis development; cell-cell adhesion; wound healing; apoptosis; intermediate filament organization; peptide cross-linking; cell structure disassembly during apoptosis. Disease: Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma; Arrhythmogenic Right Ventricular Dysplasia, Familial, 8; Keratosis Palmoplantaris Striata Ii; Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis; Skin Fragility-woolly Hair Syndrome; Epidermolysis Bullosa, Lethal Acantholytic

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095