catalog number :
MBS9337240
products type :
ELISA Kit
products full name :
Human Melanocortin receptor 4 (MC4R) ELISA Kit
products short name :
Melanocortin receptor 4 (MC4R)
products name syn :
melanocortin 4 receptor; MGC126851; MGC138197;
other names :
melanocortin receptor 4; Melanocortin receptor 4; melanocortin receptor 4; MC4-R; melanocortin 4 receptor
products gene name :
MC4R
other gene names :
MC4R; MC4R; MC4-R
uniprot entry name :
MC4R_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_005903.2
ncbi gb acc num :
NM_005912.2
ncbi mol weight :
36,943 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Peptide GPCRs Pathway (198897); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114)
ncbi summary :
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
uniprot summary :
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity. Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 18q22. Cellular Component: plasma membrane; integral to membrane; nucleus. Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; melanocyte stimulating hormone receptor activity; peptide hormone binding; ubiquitin protein ligase binding. Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus. Disease: Obesity